How does peaCURE work?

Our peaCURE is pharmaceutical grade palmitoylethanolamide which is an endogenous fatty acid amide naturally produced inside the body which, when ingested, nutritionally  may provide relief against pain and inflammation, but also to support cell and muscle recovery and prevent unwanted changes in cells.

This makes the mechanism behind peaCURE completely safe and effective for a variety of conditions.


Here is more about the mechanism itself:

Our cells have a large number of receptors on their surfaces. When something binds to these receptors they trigger an intracellular process of some kind inside the cell. It depends on the kind of the receptor what molecule can bind to it and what kind of a process it triggers inside a cell, but whenever that molecule binds to it, the signal is sent inside the cell and the process is initiated.

Below you will find a list of receptors that peaCURE affects and a short introduction to their respective effects so that you can get a hint of how efficient and versatile peaCURE is. The way peaCURE affects these receptors is either through direct binding or via other endogenous substances, such as anandamide, which plays a major role in regulating pain in the body.

1. PPAR-alpha
PPAR-alpha is the primary target of peaCURE. It is one of the most versatile receptors in our bodies found on the cells in the adrenal gland, kidneys, brown adipose tissue, heart, skeletal muscle, liver, large intestine, small intestine… It is also an integral part of ketogenesis. In each of these positions PPAR-alpha exerts a number of different positive effects and its gene ontology further exposes an incredibly wide array of positive effects all over our bodies.

2. GPR119
GPR119 is present in our gastrointestinal tract and pancreas. Some of its major functions include regulating food intake and secretion of insulin and incretin. Food intake regulation may make peaCURE a perfect diet pill which reduces the amount of food you take in without any negative effects or starvation.

3. GPR55
This G-protein receptor was discovered recently and it is present in the brain (cerebellum, jejunum and ileum), but also in other places where it regulates the function of bone cells. More recent studies are further investigating the effects of GPR55 as it seems to be a very important part of our internal endocannabinoid system.

4. CB1
CB1 is another incredibly important receptor which is found in the central nervous system, but also liver, lungs and kidneys. The effects of peaCURE on CB1 are not direct, but they are significant. The benefits come through the so-called Entourage effect with anandamide, an endogenous substance which exerts a variety of positive effects and affects the CB1 directly. peaCURE helps anandamide work a lot better, as we will explain below.

5. CB2
CB2 is extremely important for immunity. It is found all over the immune system, B cells, hematopoietic cells and macrophages.

Together with the mentioned receptors peaCURE also deals nutritionally with mast and glial cells and also reduce iNOS and COX-2 expression which produce the feeling of pain, as well as neutrophil influx.


Connection with anandamide

Anandamide, also known as AEA, is another substance which is naturally present in our bodies.

Just like palmitoylethanolamide, anandamide is completely safe, but it has one problem. It is quickly broken down in the body by the FAAH enzyme. All its effects come in a very short time before FAAH gets to it.

peaCURE has similar pathways to the ones of anandamide and it increases its effects. Moreover, FAAH is also responsible for breaking down peaCURE molecules, which means that an increased amount of peaCURE means that FAAH has to work a lot longer before it can dissolve both peaCURE and anandamide. This means that both of these compounds can exert their positive effects for noticeably longer.


The buildup period

The buildup period is the time it takes for peaCURE to reach the levels inside our bodies which allow it to exert its positive effects. Its length depends on two things: individual absorption capacities and the severity of the health condition.

For example, if the pain a person is feeling is severe and chronic, the person might need more peaCURE to deal with it. Simply taking a lot of peaCURE at once, even though completely safe, does not solve this problem, since we can’t absorb a lot of it at once. All of it that we do not absorb will simply be broken down by enzymes and wasted.

This is why it takes some time for the cells to absorb the necessary amounts. The buildup period is highly individual and it lasts between a few days to about three months. However, most people experience significant benefits within the first four weeks.


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