What Does Immunocompromised Mean?

This is an expression used to describe a person whose immune system does not work as it should – it can be performing weaker or not work at all. The state is often referred to as immunodeficiency and it greatly decreases or even completely eliminates the body’s power of protecting itself.

In most cases, immunity gets compromised due to acquired factors, rather than hereditary conditions, but not exclusively. The causes can range from diseases such as HIV which is notorious for destroying immunity, to nutrition, to side effects of some drugs which promote immunosuppression. This is called secondary immunodeficiency.

Primary immunodeficiency, on the other hand, occurs in the far less common case when the causes for immunodeficiency are intrinsic.

Regardless of the kind, all immunocompromised people have lowered ability to battle infections. This makes them more susceptible to health related issues as well as to the so-called opportunistic infections. These infections are the ones which rarely or never affect people which are healthy.


As already mentioned, there are many different causes which can make people immunocompromised. Some of them are genetic, inherited and present from day one, but most are acquired and come from various infections and even various kinds of cancers such as leukemia, myeloma and lymphoma.

Most diseases affect immunity in some way, as does the medication used to treat many diseases. This makes it easily understandable why when some of these diseases are chronic, the people who suffer from them become immunocompromised. This is most common for people with renal diseases in the final stages, liver cirrhosis, diabetes and more.

Immunosuppressive Disorder
Immunosuppressive Disorder
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HIV causes immunodeficiency. It reduces the number of T cells which are very important for proper functioning of immunity. The number of these cells is measured using CD4 count. When this is under 200, people are diagnosed with AIDS. The more the disease progresses, the lower the CD4 number becomes and the more susceptible to various infections the patients become.

Some people can lack spleen or suffer immunodeficiency due to other similar anatomic issues.

Medications can also lead to immunodeficiency. Chemotherapy and radiation hamper immunity, as do numerous steroids. Moreover, some patients have deliberately reduced immunity. Just as one example, this is necessary for patients who have had transplantation and require immunosuppressive medicines.

Immunocompromised patients often become so after taking medication used to improve some other condition. Moreover, some conditions are actually caused by improper performance of the immune system, so immunosuppressants are used to attack the immune system and improve the condition. Just some of these issues include things like multiple sclerosis, rheumatoid arthritis, Chron’s disease, psoriasis, lupus, autoimmune hemolytic anemia and hepatitis, ITP, myasthenia gravis, ulcerative colitis and more.

Lastly, several natural physical states can reduce immunity. For example, this is so even with pregnancy. Similarly, immunity of babies is not well developed.
Many cases of secondary immunodeficiencies come from aging or malnutrition, but also from smoking, alcohol and drug abuse.


The varying nature of immunodeficiency also affects the prognosis. Some of them can lead to mortality, especially with babies with immunodeficiency, while other kinds can cause little issues and last a lifetime.


A somewhat novel treatment option for genetic immunodeficiency is stem cell transplant. More conventional and more common treatment options include either treating infections or improving the general state of the immune system.

Administering immunoglobulin is another option often used mainly for primary immunodeficiency. It can be administered either through intramuscular injections or subcutaneous and intravenous infusions. In the case of subcutaneous injections, the necessary levels are higher than for intravenous administration.

Immunoglobulin can cause some adverse effects, such as nausea, chills, fever, backache and fatigue. Luckily, the side effects last up to a few hours after the treatment, after which they subside. The side effects can also be reduced if you opt to make short pauses during infusions. Moreover, they can be treated using medicines, including corticosteroids. However, they do come with additional side effects.

Another option is peaCURE and it is the easiest of them all. peaCURE is the name for a medical food which is consisted of pharmaceutical grade palmitoylethanolamide.


Palmitoylethanolamide is produced inside the body and its main purposes are improving muscle recovery and reducing pain and inflammation. It works by affecting a number of receptors on the surfaces of cells.

It binds directly to some of these receptors, while it affects the others through its positive interactions with other endogenous compounds such as anandamide, also known as the bliss molecule. For example, this is the way it affects CB2, which is a receptor in charge of the immune system. It regulates the operation of B cells, macrophages and hematopoietic cells.

This means it helps create blood cells and antibodies, clear out toxins and cellular debris and also eliminate microbes and cancer cells. For example, macrophages examine the surface of cells looking for proteins found on normal, healthy ones. When it fails to find these proteins, it eliminates the unhealthy cells.

peaCURE also reduces inflammation and calms the inflamed cells, such as mast and glial cells.

However, aside from its efficacy, peaCURE has another major benefit – safety. Most procedures are invasive and most medicines come with side effects. However, peaCURE has no side effects. This was tested in more than 400 medical studies over the past 60 years and not a single recurring side effect was found.

Secondly, there is no overdose level, since all excess palmitoylethanolamide gets dissolved by enzymes in the body.

Next, there are no negative interactions with any other drug you might be taking at the moment.

Simply put, peaCURE is well worth a try. It is effective, natural, safe and thoroughly tried and tested. Improving immunity has never been easier and safer.

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