Palmitoylethanolamide (peaCURE), is a fatty acid amide, and is a naturally occurring substance within our bodies. Fatty acid amides are, as the name suggests, an amide formed from a fatty acid and an amine. Amines are a functional group that consist of a nitrogen atom in combination with three carbon atoms and/or hydrogen atoms. Fatty acid amides are vital to the chemical signaling processes within our bodies.
Palmitoylethanolamide is produced within our cells, and within the body it contributes to the homeostasis, or balance, of the body.
First identified in Czechoslovakia in 1952, palmitoylethanolamide was initially brought to market by pharmaceutical company Spofa in the late ‘60’s. It was introduced using the brand name Impulsin. The same drug was introduced to Spain by Almirall under the brand name Palmidrol in 1976. After more than a decade on the market, the drug disappeared as the Czechoslovakian manufacturer ceased production. There are many scientific articles about palmitoylethanolamide, which can be found on the medical database Pubmed.
Rita Levi-Montalcini & Palmitoylethanolamide
Rita Levi-Montalcini, a Nobel Prize winner, found a relationship between palmitoylethanolamide and anandamide during her research throughout the 1990’s. Anandamide, whose name is a derivative of the word Ananda, which means happiness in Sanskrit, is a neurotransmitter. Anandamide is found naturally in the body. This substance is closely associated with the regions of the brain that are responsible important processes. These include happiness, the higher thinking processes, fertility, memory and motor control.
Since the initial discovery of palmitoylethanolamide up to 2015, there have been around 500 separate studies on the properties of palmitoylethanolamide for human health. Palmitoylethanolamide is a substance that has gained popularity amongst researchers, clinicians and pharmacologists around the world. So much so that in 2012 the very first palmitoylethanolamide Conference was held. At the event, over 100 researchers from a wide variety of different countries discussed the properties, potential and applications of palmitoylethanolamide.
Pain relieving supplement
Palmitoylethanolamide (peaCURE) binds to nuclear receptors in cells and produces a variety of effects that help deal with chronic pain and inflammation. This is our bodies’ way of battling these issues and it works rather well, since palmitoylethanolamide is a natural substance with no side-effects whatsoever.
The problems occur when the pain is chronic, since our bodies can’t produce enough palmitoylethanolamide. The help comes in the form of capsules containing palmitoylethanolamide as a supplement. This is the perfect way to increase the amount of palmitoylethanolamide in your organism to help you deal with almost any kind of pain.
Moreover, since it is basically a fatty acid amide, there is no way to overdose on it and having in mind that it has no side effects and that there have been no known issues that come from combining it with other medicine, PEA seems like the perfect choice for anyone experiencing any kind of pain.
It does take some time for the substance to build up in the body and provide the wanted results. This is why it is very important that you can use it with other medicine. As the palmitoylethanolamide concentration builds up and starts to provide results, you can reduce (or even completely cut out) the amounts of medicine that usually come with side effects and damage liver and kidneys.
We have examples of severely positive effects on the patients suffering from chronic osteoarthritis and joint pain at wrists, knees or hips, hip arthrosis, back pain, menstrual pain…
Fever reducing supplement
Using palmitoylethanolamide (peaCURE) is a way to deal with fevers that is as natural as the cause of fever itself. Our peaCURE has been known to relieve pain and have great anti-inflammatory effects, but it has been proven to stabilize the mast cells as well. These cells play an important role when it comes to hay fever and managing their operation can have extremely positive effects on reducing inflammation.
Higher concentrations of pollen in the air make the mast cells overly active and they produce substances that cause the symptoms of hay fever.
Hay fever is usually controlled by using antihistamine. However, they have very adverse side effects. Palmitoylethanolamide has no side effects; it can be given to children and there is virtually no way of overdosing. Moreover, palmitoylethanolamide can be used as prevention. This is very important as hay fever is a recurring condition whose timing can be estimated somewhat accurately, so taking peaCURE for prevention can completely remove problems with fever.
Palmitoylethanolamide can be found in our bodies as it is a natural compound that is used to reduce inflammation and pain. Ever since 1980s scientists have known about amazing anti-inflammatory effects of palmitoylethanolamide. In about two decades before that there had been numerous studies that separated palmitoylethanolamide from other anti-inflammatory treatment methods due to its fantastic effects and utter lack of side effects which makes it perfectly suitable for children as well.
One of the studies from 1975 published in The Lancet compared the effects of 3 g of aspirin a day to 1.8 g of palmitoylethanolamide a day. The effects of both were noticeable improvements in join movement and reducing pain.
In early 1990s a Nobel prize winner Rita Levi-Montalcini and her team demonstrated the effects of palmitoylethanolamide on mast cells and their stabilization.
Aside from being an effective treatment for inflammation, palmitoylethanolamide can also be used to prevent inflammation in the first place. Moreover, using it as prevention bears no dangers whatsoever. Taking peaCURE has no side-effects and overdosing is virtually impossible.
Homeostasis regulating supplement
The brain uses a lot of energy and it is the place where many free radicals are formed. This can cause serious issues with nerve tissue and palmitoylethanolamide may serve as the most natural and effective protection. The same goes for ischemia-reperfusion injury which has been known to occur after a stroke, as well as various acute damages that may affect the central nervous system.
Palmitoylethanolamide has this effect mostly due to its ability to bridge the gap between blood and nerves. It can at the same time provide protection for the nervous tissue and blood vessels and thus give complete defense for the entire system. Aside from reducing inflammation, peaCURE also re-establishes homeostasis levels of nitrotyrosine and iNOS.
One of the most useful perks of peaCURE for treating conditions of this kind of severity is the fact that it is completely natural and completely safe for anyone including children.
Immune system boosting supplement
Effects of palmitoylethanolamide for treating cold and flu are well documented. The same goes for battling fevers and any kind of inflammation. Its popularity is even more boosted by the fact that it has no ill effects and that it is completely natural. What is less familiar is the mechanism that lies behind this effectiveness.
Its importance became familiar in the 1970s after several double blind and placebo controlled studies. These proved that there are absolutely no side effects and that palmitoylethanolamide can be used by senior patients and children alike.
Two of the studies were conducted in the military and among workers in the Skoda automobile factory. Another one was conducted in 1997 on 457 school children. All of these studies proved that palmitoylethanolamide helped with reducing respiratory system inflammation. However, even more importantly, they showed that using palmitoylethanolamide as prevention had incredibly positive effects on reducing the chance of becoming sick in the first place.
Palmitoylethanolamide is also important because the most commonly present ways of prevention, such as vaccines, have had problems battling the changing nature of the flu and cold, not to mention their well-documented side-effects. Our peaCURE has none of those. Vaccines can provide protection against exactly those kinds of viruses they are aimed at, while peaCURE is the natural way that our own bodies use to tackle inflammation and other conditions, so its effects are universal. There seems to be no other way of providing yourself with such combination of effectiveness, safety and reliability that palmitoylethanolamide gives.
Allergies reducing supplement
When a person gets in contact with an allergen, their body makes antibodies and these antibodies attach themselves to mast cells. The next time the same person gets in touch with the same allergen, those mast cells release things like histamine and cytokines and they cause the all too familiar allergy symptoms that can make our days a living hell.
Moreover, mast cells are present all over the body, so the inflammatory elements can reach a wide variety of places inside our bodies. Palmitoylethanolamide has been very effective when it comes to stabilization of mast cells. Plus it affects mast cells wherever they are, since it can affect places as varying as blood and nerves.
Large numbers of studies also showed that using palmitoylethanolamide together with prescribed medication has no bad effects. Palmitoylethanolamide is naturally present in our bodies and it comes with zero side effects, while having great effects for treatment, prevention and relieving symptoms as well. Lastly, since it can be safely taken alongside medication, you can in time reduce the amount of drugs and thus preserve your health.
Palmitoylethanolamide has amazing effects when it comes to relieving problems for patients with MS pains and spasms, and also the ones with Parkinson’s disease. Most of these problems have been treated with things like Valium, baclofen, gabapentine and pregabaline, but these do come with severe side effects. Others have used cannabis, but it is not something that all people want to use and it is illegal in many countries.
On the other hand, peaCURE is completely safe, natural, legal, readily available and has no side effects. But is it effective? Actually, more than that. In the past few years there have been several researches that focus on how our own bodies perform natural repair mechanisms. These have found several substances produced by our own bodies that perform this mechanism and one of the most prominent ones is palmitoylethanolamide. Adding it as a supplement can severely reduce the most common issues following the neurodegenerative diseases.
More importantly, it can also work as prevention. A brain with Parkinson’s disease suffers from degeneration of nerve cells in a particular part of the brain. Palmitoylethanolamide protects nerve cells from degeneration and thus treats cause and not only symptoms.
Chronic pain also brings depression. It is more than familiar how effective peaCURE is against chronic pain, which means that it can also reduce one of the most common causes of depression. However, recent research shows that it can also positively affect depression itself.
A damaged nerve that causes chronic pain also causes a metabolic change. These metabolic dysfunctions also result in depression and the researchers have found that various antidepressants naturally increase the levels of palmitoylethanolamide in the brain. This goes even for the more common ones such as imipramine, escitalopram and tianeptine. They come with a downside of several side effects.
However, if the result of taking said antidepressants is actually increasing the amounts of palmitoylethanolamide in the brain, why not just take palmitoylethanolamide as a supplement and thus increase its amount and completely avoid any side effects and damage to organs.
Our peaCURE can show the first signs of relieving pain within days or weeks. Dr Di Marzo and his team conducted a research that the above idea of taking palmitoylethanolamide instead of medication that causes the increases of palmitoylethanolamide levels actually works in practice. Using peaCURE not only decreases pain, but also works rather well as an antidepressant and all this without any side effects, or problems when mixed with other medicine.